Skip to content
i2E
  • Programs
    • For Startups
      • E3
      • Bridge2
      • OCN
    • For Students
      • Entrepreneur’s Cup
    • For Corporations
    • For Investors
  • Client Portfolio
  • About
    • Our Values
    • Meet Our Team
    • Board of Directors
    • Corporate Partners
  • Events
  • Contact
  • Media
  • Programs
    • For Startups
      • E3
      • Bridge2
      • OCN
    • For Students
      • Entrepreneur’s Cup
    • For Corporations
    • For Investors
  • Client Portfolio
  • About
    • Our Values
    • Meet Our Team
    • Board of Directors
    • Corporate Partners
  • Events
  • Contact
  • Media
Search

Innovators: Naturalock Solutions

Get in Touch

Innovators: Naturalock Solutions
By Brian Brus
Copyright © 2015 The Journal Record

NORMAN – Naturalock Solutions LLC has issued its first patent for what company President Gary Rayburn called a solution to significantly reducing catheter infections and health complications.

Development of the transdermal venous access locking technology – an injectable liquid to replace commonly used chemicals such as heparin and saline – had stagnated under the licensing of another company for more than two years, Rayburn said. Now Naturalock will be able to move forward unhindered under its parent Organic Medical Ventures LLC.

Rayburn credited the efforts of intellectual property attorney Bryan Fuller at the Hall Estill law firm in Oklahoma City for a quick rebound from the previous business relationship and filing the patent with the U.S. Patent and Trademark Office. The patent will be instrumental in commercialization of the Karaphor solution, he said.

Catheters are effectively open wounds and the needle resting in pierced flesh provides a lot of opportunity for infection, Rayburn said.

Catheter-related bloodstream infections are one of the top health care challenges in the industry as identified by the federal Centers for Disease Control and Prevention. More than 400,000 cases are reported annually, resulting in mortality rates as high as 25 percent. On the level of cost analysis, catheter infections are estimated to increase treatment costs $25,000 to $55,000, according to CDC data.

Karaphor is made from naturally occurring substances that help prevent coagulation and improve antimicrobial activity in catheters. The solution was designed to be flushed into a patient, a different approach than using products such as saline and heparin that need to be withdrawn and do not provide any antimicrobial properties.

“Our product would be utilized as a preventative measure,” he said. “If you have the option of curing a disease or preventing it, the best solution is obviously to prevent it to begin with.”

With Fuller’s help in defining the product’s widespread implications, the patent will also make it easier for Naturalock to commercialize a platform for related applications such as military field use, he said.

Naturalock is seeking partners to help commercialize the product and its potential portfolio, Rayburn said. He thanked the Norman Economic Development Coalition for its support during the company’s growth.

More News

Loading...
Blog, Featured, News
12.17.25

Empowering the Next Generation of Innovators

Read more
Blog, Featured, News
11.07.25

Taming the Paperwork Problem in Nursing: The CerTracker Story

Read more
Blog, Featured, News
07.07.25

i2E Names Darcy Wilborn as President

Read more
Blog, Featured, News
06.25.25

i2E Showcases Startup Innovation at Bridge2 Cohort 3 Demo Day

Read more
Blog, Entrepreneur's Cup Featured, Entrepreneur's Cup News
04.25.25

Oklahoma Collegiate Entrepreneurs Take Home Over $167K at Entrepreneur’s Cup

Read more
Blog, Featured, News
12.16.24

MidAmerica and i2E Announce Award Winners

Read more
Blog, Featured, News
11.21.24

i2E & Plains Ventures Surpasses $100M Milestone in Total Investments

Read more
Blog, News
09.30.24

i2E Receives 2024 Excellence in Economic Development Award from IEDC

Read more
Blog, Featured, News
06.18.24

Bridge2 Demo Day Returns, Highlighting Promising Oklahoma Startups

Read more
Blog, Entrepreneur's Cup Featured, Entrepreneur's Cup News
05.13.24

Student Entrepreneurs Triumph at 20th Anniversary Entrepreneur’s Cup, Winning $158,000 in Prizes

Read more
Default Featured Image
Blog, Entrepreneur's Cup News
04.24.24

Beyond the Cup: Tracking Success Stories from the Entrepreneur’s Cup Series – Jessica Kinsey

Read more
Default Featured Image
Blog, Entrepreneur's Cup News
04.23.24

Beyond the Cup: Tracking Success Stories from the Entrepreneur’s Cup Series – Nathan Fountain

Read more
i2E

Oklahoma City Office

201 Robert S Kerr Ave, Suite 600
Oklahoma City, OK 73102
+1 (405) 235.2305

Tulsa Office

12 N. Cheyenne Ave, Suite 112
Tulsa, OK 74103
+1 (918) 582.5592

i2E, Inc. is committed to making all our programs, activities, and events accessible to everyone who wants to participate. If you need a specific disability-related accommodation or service, please contact: Ashley Corral [email protected] 918.582.5592

Please contact Ashley Corral at least ten (10) business days prior to the function you are attending. We will make every reasonable effort to accommodate you.

  • Client Portfolio
  • About Us
  • Media
  • Events
  • Contact
  • Resources
  • Funding
  • Venture Advisory

© 2026 i2E Privacy Policy

Follow us:

Linkedin Twitter Facebook Instagram Youtube

Programs

  • For Startups
    • E3
    • Bridge2
    • OCN
  • For Students
    • Entrepreneur’s Cup
  • For Corporations
  • For Investors
  • For Startups
    • E3
    • Bridge2
    • OCN
  • For Students
    • Entrepreneur’s Cup
  • For Corporations
  • For Investors
  • Client Portfolio

Services

  • Access to Funding
  • Venture Advisory Services
  • Events
  • Contact
  • About
  • Our Values
  • Our Team
  • Board of Directors
  • Corporate Partners
  • Media
i2E